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The activation of Bax leads to its translocation to the mitochondria, disrupting the membranes permeability

In cancer cells, pyruvate is continually converted to lactate in the cytoplasm, thus hampering glucose entry into mitochondria

Visual inspection was conducted for each spectrum, excluding poorly fitted spectra from analysis

This increase in cytokine production further increases oxidative stress which in turn affects mitochondrial functioning and disrupts the production of ATP

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Funding CWI is supported by the Interdisciplinary Center for Clinical Research (IZKF) at the University of Wrzburg (A-303 to CWI, A-421 to CWI and JWi, N-362 to CWI), by the Deutsche Stiftung Neurologie and the ParkinsonFonds Germany and by the University Research Funds of the State of Bavaria