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BPC-157 equaled or exceeded imipramine (a standard tricyclic antidepressant) in forced swimming tests, the gold-standard animal model of antidepressant action

Thus, since the other generally known stress parameters are apparently less disturbed (i.e., thymolymphatic involution and cortical hypertrophy of the adrenal glands), it is evident that NaBPC157 could be applied in various stress conditions

Therefore, if such significant endogenous PAMs of GABA A Rs are found in the periphery, it begs the question of whether other such chemicals exist

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Carey Nease MD

Sci Rep 10:5227