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As a result, lower drug administration requirements are feasible [17], so no modification of the therapeutic agent nor coupling the drug to any carrier is required [11]

Serious reactions are uncommon, and Dr

Precaution:Avoid direct contact with eyes

This difference may be explained by the results of in vitro binding studies, which showed that daratumumab can directly bind CD38 on RBCs, whereas isatuximab requires a cofactor (e.g., a mouse anti-CD38 antibody or a CD38 inhibitor), suggesting masking of the isatuximab epitope on RBCs in some patients [49, 50]

10.1016/0197-2456(95)00134-4 29 KimH.-I.HyungW

Pandey et al