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Experimental sleep deprivation leads to endothelial dysfunction, an early marker of atherosclerosis, as indexed by impaired endothelial-dependent vasodilation or increased levels of endothelial adhesion molecules 191

However, some men develop a troubling side effect called gynecomastia, or male breast enlargement

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[5] Similarly, individuals who have undergone gastrointestinal surgery particularly gastric bypass, gastrectomy, or ileal resectionoften have impaired B12 absorption and require supplementation