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The dsRNA replicative intermediate is a potent pathogen-associated molecular pattern (PAMP) sensed by pattern recognition receptors (PRRs) in the cytoplasm (RIG-I-like receptors (RLRs)) and the endosome (Toll-like receptor 3 (TLR3))

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The diverse function and severe diseases in the absence of LROs suggest a general role in self-protection at the organismenvironment interface

Furthermore, abnormal D 2 R and D 3 R expression was observed in brain regions associated with both motor and nonmotor symptoms of PD

(2004) ROS undergo a crucial oxidative change through the cysteine-to-heme enzyme of reticular membranes, found in the endoplasmic reticulum