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Through promotion of kynurenine accumulation, Tregs induce indoleamine 2,3-dioxygenase (IDO) expression in dendritic cells, which results in tryptophan depletion and immunosuppression, as kynurenine enhances Treg proliferation and suppresses Teff cells [25, 27]

VelzquezKTEnosRTNarsaleAAPuppaMJDavisJMMurphyEAet al

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This analysis strengthens the increasing body of work identifying altered antioxidant responses as a potential contributor to cognitive impairment

Synergy of IL-27 and TNF- in regulating CXCL10 expression in lung fibroblasts