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Thus, unlike most other animal species, which can synthesise ascorbate in their livers or kidneys [2], humans and other ascorbaterequiring animals must obtain the vitamin through dietary intake, with fresh fruit and vegetables being the primary dietary source of the vitamin [3]

494 Lifestyle modification Lifestyle modification plays a pivotal role in the prevention and management of DN

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doi:10.1016/j.xkme.2023.100704

However, the shortcomings of melatonin, such as its low bioavailability, rapid metabolism, and significant individual variation in secretion, have limited its clinical application in anticancer therapy