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Mutations in the transcobalamin gene can cause a deficiency

Yes, fatigue and neurological symptoms can occur before anaemia develops, and some patients have normal haemoglobin levels despite B12 deficiency

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In the emergency room, treatment for severe migraines may involve intravenous medications, such as anti-inflammatory drugs or analgesics, to provide fast-acting pain relief

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[2] Neurological manifestations include subacute combined degeneration of the spinal cord and peripheral neuropathy (in the form of glove and stocking paraesthesia and trichodynia)
