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Advancements in single-cell RNA sequencing have characterized previously unrecognized spatial heterogeneity and immune functions of stromal cells in the lymph nodes (114, 122, 123, 125, 130, 131), suggesting that the disintegration of the highly organized stromal cell structure will impair the anti-cancer immune responses (132)

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This granular control helps some users manage side effects more effectively

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While most studies including those in children attempted treatment withdrawal in patients having sustained biochemical remission (normalization of transaminases for more than 2 years)