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Instead of overproducing melanin in response to damage which creates dark spots and uneven patches they maintain a more balanced output

[DOI] [PubMed] [Google Scholar] Brauner-Osborne H, Egebjerg J, Nielsen EO, Madsen U, Krogsgaard-Larsen P

Murray S

10.1371/journal.pone.0175262 141 ZhangS.LiaoX.ChenS.QianW.LiM.XuY.et al (2022)

Direct and prolonged contact of copper with skin may result in electrochemical reactions to release copper ions, which are diffusible through the skin 2

A key piece of context: levels of both NAD+ and glutathione decline significantly with age