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Raloxifene, a selective estrogen receptor modulator (SERM), prevents chemically induced ferroptosis in neuronal cells by inhibiting the protein disulfide isomerase (PDI) pathway

PL significantly increased ROS levels and protein glutathionylation with a concomitant elevation in Nrf-2 expression, thus inducing the redox imbalance to kill two human colon cancer cell lines with mutant p53, HT29 and SW620 ( Trigonelline (TRG) is a plant alkaloid in Trigonella foenum-graecum L

However, a more recent study observed that physiological levels of oncogene (KRAS G12D and MYC) expression could trigger a NRF2-dependent antioxidant response to downregulate ROS levels in cells [8]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Demeule M

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