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Molecular insights into the differences in anti-inflammatory activities of green tea Catechins on Il-1 Signaling in rheumatoid arthritis synovial fibroblasts

4 Figure 1

After exposure to oxidative stimuli, Nrf2 dissociates from Keap1, its negative regulator, and translocates into the nucleus where it heterodimerizes with small Maf proteins [77] and binds to antioxidant responsive element (ARE) sequences, triggering a cytoprotective adaptative response

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Some recent studies show that high doses of apigenin can inhibit the proliferation of DCs, and can also reduce the protein expression of programmed death-ligand 1 (PD-L1) in DCs by inhibiting the phosphorylation of STAT1, thus inducing anti-cancer immunity [48, 49]