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This study demonstrated that CD-based polyrotaxanes can provide a transformative solution to drug delivery challenges, achieving controlled and targeted drug release with enhanced therapeutic efficacy

Funding This study was supported by a research grant (3251) from Shahrekord University of Medical Sciences, Shahrekord, Iran

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Acknowledgements We would like to thank Instituto do Osso e da Cartilagem for the support and Jos Fbio Lana for his remarkable academic contributions towards the production of this manuscript

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