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Importantly, daratumumab exerts greater CDC in the presence of low levels of complement inhibitors such as CD55 and CD59 [35]

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IGF-1 mediates many of growth hormones anabolic effects, including muscle protein synthesis, bone growth, cartilage formation, and cellular proliferation

A decrease in the normal levels of plasma proteins results in a decrease of colloid osmotic pressure (which counterbalances the hydrostatic pressure) in the capillaries