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According to the brand, in their opinion, a lot of it comes down to the emotional weight the product carries

doi: 10.1016/j.pneurobio.2016.05.001

Accumulation of cytosolic succinate results the inhibition of the 2-oxoglutarate and Fe 2+ -dependent dioxygenases [prolyl hydroxylase domain (PDH) enzymes] responsible for the hydroxylation of the -subunit (HIF-1) of HIF-1

A 2022 UK study found that of those with B12 deficiency, pernicious anaemia was the underlying diagnosis in nearly half of the cases, making it a major cause

[DOI] [PubMed] [Google Scholar] 210.Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, Geurts L, Naslain D, Neyrinck A, Lambert DM, Muccioli GG, Delzenne NM

In mitochondrial dysfunction, the aberrant transfer of electrons along the respiratory complex chain is thought to result in the generation of ROS by the spurious reduction of molecular oxygen (37, 75)