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Despite small randomized trials suggesting that patients with a high supplementation risk of preeclampsia with antioxidants may be beneficial, the overwhelming evidence from large, randomized, and placebo-controlled trials clearly found that vitamin supplementation in pregnancy does not prevent the development of preeclampsia

Single vials and bulk quantities are available for ongoing study protocols

doi: 10.21037/atm.2017.03.50 99

This is not an indication that the product has spoiled

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These findings suggest that L-methylfolate may be effective in reducing depression symptoms and improving functioning in a naturalistic setting