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This mechanism plays a role in activating various downstream pathways, including RAS/MAPK, PI3K/AKT, Wnt/-catenin, and JAK/STAT, which are crucial for controlling a range of cellular physiological activities such as differentiation, proliferation, epithelial cell movement, angiogenesis, and EMT [21]

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Oxidative stress was studied in duodenal and sigmoid biopsies from 15 cirrhotic patients and 22 controls by analyzing transcription of genes involved in glutathione and uric acid metabolism using quantitative real-time polymerase chain reaction