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The pathway is quite efficient: for example, it maintains the ratio NADPH/NADP+ at ~100 in the liver of a normal healthy individual

Stimulation of dermal fibroblast proliferation was chosen to verify activity of engineered PDGF-BB, while the activity of engineered IL-1Ra was verified by measuring its capacity to inhibit IL-6 release by macrophages in response to IL-1

A phase II human trial was initiated for ulcerative colitis, with encouraging preliminary results

Data availability The data that support the findings of this study are available within the paper and its Supplementary Information files, or are available from the corresponding authors upon reasonable request

Combining these approaches with 5-amino-1mq could theoretically produce enhanced effects on cellular energy and fat metabolism

Activation of the Nrf2 pathway leads to the induction of antioxidant and detoxifying enzymes, significantly reducing oxidative stress