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The methyl group is what gives b12 it's medicinal quality

Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes

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Springer Nature, Singapore, pp 321337 Sekikawa T, Kizawa Y, Li Y, Miura N (2023) Effects of diet containing astaxanthin on visual function in healthy individuals: a randomized, double-blind, placebo-controlled, parallel study