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Conjugating small molecule drugs with Tf enhances the permeability of hydrophilic chemotherapeutic or neurotherapeutic agents into tumor cells or across the BBB

While passive diffusion was initially proposed as the main absorption route, recent evidence indicates that specific transmembrane transporters including Na-taurocholate cotransporting polypeptide, organic anion-transporting polypeptides, L-type amino acid transporters, and monocarboxylate transporters also facilitate LT4 uptake

& Nishikawa, J.-I

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A single instance of leaving your vial at room temperature overnight can denature the protein structure irreversiblyturning an expensive research compound into sterile water with no visual indication that anything changed