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Glutathione is a powerful antioxidant that the body relies on

Up-regulation of miR-21 promotes cell proliferation and collagen synthesis in pulmonary fibroblasts

(10) Cigarette smoke is known to deplete the cellular glutathione pool in the airways, exacerbating oxidative damage and inflammation in the lung, which is likely the reason why smokers with COVID-19 more likely require intensive medical interventions

Interestingly, several components of the nucleosome remodeling and deacetylase NuRD complex (including CHD4, HDAC1/2, MBD3, among others

Dietary modification alone is insufficient for treating established deficiency but plays a supportive role in prevention

Additional information Peer review information Nature Communications thanks Yusuke Inoue and the other, anonymous, reviewer(s) for their contribution to the peer review of this work