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H 2 O 2 , O 2 -, OH-, etc.) are produced by aerobic cells under physiological conditions

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However, the signaling pathway for Mac-1 clustering-induced EV biogenesis by neutrophils appeared to be divergent from the signaling pathway for phagocytosis, independent of Syk and Src kinases, but dependent on PLC2 and intact calcium signaling 10

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