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SHMT2 desuccinylation by SIRT5 drives cancer cell proliferation

To test whether the MTS pathway was supporting the TR/GR-null livers, we treated mice with single-dose challenges by inhibitors of cystine uptake (sulfasalazine, SSZ), possible cysteine uptake (2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, BCH), conversion of methionine into cysteine by MTS (propargylglycine, PPGG, which inhibits trans -sulfuration and not the methionine cycle), or synthesis of GSH (BSO) 11

Free Radic Res 50 , 1425 (2016)

122 The authors concluded that NAC may improve markers of inflammation or oxidation, systemic oxygenation, the need for/duration of ventilation, rate of patient recovery and clinical improvement score, whilst effects on length of stay, CT/x-ray images, mortality rate and pulmonary complications were inconclusive

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doi: 10.1111/ijd.15573