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[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Paul A, Gunewardena S, Stecklein SR, Saha B, Parelkar N, Danley M, et al

Specific aquaporins facilitate Nox-produced hydrogen peroxide transport through plasma membrane in leukaemia cells

NNMT had previously been identified as upregulated in obese adipose tissue, several solid tumours, and ageing tissue more broadly, where its activity correlates with depleted SAM and elevated 1-methylnicotinamide (MNA)

The beads were washed 4x with cold PBS, and an equal amount of 1xSDS loading buffer was added to each sample, after boiling for 5 min, proteins separated by SDS-PAGE were detected by Coomassie Brilliant Blue staining
doi:10.1016/j.jacl.2017.06.008 Mackey, Rachel H et al

In accordance with this, pathway analysis of the RNA transcriptome identified oestrogen-mediated S-phase entry, p53 signalling and G1/S checkpoint regulation as canonical pathways significantly modulated in response to GSTO1 knockdown (Supplementary Fig
