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### Competing Interest Statement DKN is a co-founder, shareholder, and on the scientific advisory boards for Frontier Medicines and Vicinitas Therapeutics

Phase II study confirms the therapeutic benefits of AOD-9604 in obesity

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When to Consider Supplementation Supplements tend to play a supportive role once foundational lifestyle factors are in place: After optimizing diet and sleep When lab work shows insufficiencies During specific life stages or increased stress, with healthcare guidance Used this way, supplements can help fill gaps rather than function as stand-alone fixes