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Following injection, AdV particles target innate immune cells like DCs and macrophages and stimulate innate immune responses by engaging multiple pattern-recognition receptors including those that bind dsDNA in particular TLR9 to induce type I interferon secretion 8

doi: 10.1007/s00394-021-02557-5 [DOI] [PubMed] [Google Scholar] 90.Husain S, Hillmann K, Hengst K, Englert H

Sachin, J

Cells are either untreated (green) or treated with LY294002 to inhibit PI3K signaling (blue), which reduces phosphorylation of Akt

J., Kassiri Z., Rubin J

Clinical Principle It is important to establish baseline values in order to evaluate later treatment responses
