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It is generated within endothelial cells through the conversion of L-arginine to L-citrulline by the enzyme eNOS

Participants were randomly assigned to placebo or NAC (1200 mg/d) groups and treated for 6 months

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Ren, 2020

Given that IGF-1 and integrin signaling share common downstream effectors such as MAPK and Akt, we propose a model ( Figure 4 ) in bone wherein mechanical stimulation results in the activation of both IGF-1R and the integrins