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ASN Neuro 14, 17590914221133236

It is highly likely that many other natural compounds used, especially in traditional Asian medicine, could have similar effects, although clinical data supporting these are lacking [117119]

Moreover, ascorbic acid significantly downregulates the expression of pro-inflammatory factors (IL-6, IL-12, and TNF-) and upregulates anti-inflammatory cytokines (IL-4 and IL-10) [140] in mouse splenocytes

Statements Author contributions FL and XDH performed the literature search wrote and revised the paper

Once mixed, a typical dose is injected just under the skin (subcutaneously), usually in the abdomen

Preliminary findings from these studies suggest a tolerable oral dosage of approximately 100mg/kg in mice [1]