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These studies show that chronic usage of APAP at recommended therapeutic levels probably does mild liver damage and may be associated with a reduction in GSH levels that compromise antioxidant defense capacity

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FASEB J 21:22262236 Kato S, Ishita S, Suguwara K, Mawatari K (1993) Cystine/glutamate antiporter expression in retinal Mller glial cells: implications for DL-alpha-aminoadipate toxicity

This accelerates denaturation

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