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Additionally, GSK3145095, a RIPK1 inhibitor, shows excellent pharmacokinetic data and is being developed for monotherapy in advanced or metastatic pancreatic ductal adenocarcinoma, as well as in combination with pembrolizumab and other anticancer agents for treating various solid tumors, including pancreatic ductal adenocarcinoma, non-small cell lung cancer, triple-negative breast cancer, and melanoma (NCT03681951) [32]

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