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These bile acids influence gut microbiota by exhibiting antimicrobial properties and modulating signalling pathways like farnesoid X receptor ( FXR) and TGR5 , which are pivotal for maintain intestinal homeostasis [44] (Table 1)

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It also have anticarcinogenic effects since it inhibits cancer cells proliferation especially colon cancer through apoptosis and controls genes expression by inhibiting the histone deacetylase activity (Havenaar, 2011)

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