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14 Upon application to the skin, DHA undergoes a Maillard reaction: the carbonyl group of DHA reacts with amino acids such as arginine, histidine, and lysine in the stratum corneum to produce brown-black chromophores, known as melanoidins, which provide a brown coloration (Figure 2)

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Within the NS region, the p7/NS2 junction is also cleaved by signal peptidase

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Besides this unique Pinless construction, Pearl flutes have additional bridge mechanisms that add strength to the entire mechanism