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Fathizadeh H, Milajerdi A, Reiner , Falahi E, Ghiasvand R, Heidari-Beni M, Amirani E, Asemi Z (2020) The effects of L-carnitine supplementation on indicators of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials

These derive from reviewers comments

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To summarize, owing to the nonlinear relationship between efficacy and dosing frequency/cost predicted in Figure 2, less frequent dosing of incretin mimetics may offer significant populationlevel public health gains for a given economic cost

Disorders of fatty acid oxidation and organic acidemias can lead to secondary carnitine deficiency by trapping free carnitine by conjugating it with acyl moieties which accumulate in these conditions