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The EPR spectrum at 77K indicates randomization of the structure around the heme-NO moiety, which is likely mainly six-coordinated (Fig

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Spontaneous reporting system data suggest that the risk of dependence and its severity appear to be greater in patients treated with doses greater than 4 mg/day and for long periods (more than 12 weeks)

While all main classes of chemotherapy agents are known to cause CIPN, vinca alkaloids and platinum compounds are used more commonly in pediatric populations and are highly associated with pediatric CIPN (Kandula et al., 2016)