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Mei D, Tan WSD, Tay Y, Mukhopadhyay A, Wong WSF

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The pathology of Parkinsons disease is influenced by a number of mechanims that lead to astrocyte dysfunction, which harms other neurons

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[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Menikdiwela K.R., Guimares J.P.T., Scoggin S., Gollahon L.S., Moustaid-Moussa N

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Thus, targeting key signaling axes related to macrophage polarization such as PI3K/Akt/-catenin, along with interaction pathways with fibroblasts such as P2rx4/IL-6/Arg1, may enable synergistic intervention against this disease

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Yet, functional imaging and peripheral biomarker measurements in patients with TRD are relatively scarce

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The carboxylesterases superfamily catalyze the hydrolysis of ester- and amide-containing chemicals

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