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For PDE1B, selectivity can be enhanced by targeting unique active-site residues, including His373 and Gln421

Since both the hydroxylation action from PHDs and ARD-1 expression require the presence of oxygen, under hypoxic condition, neither hydroxylation nor acetylation of HIF-1 proline and lysine residues occurs, resulting in stabilization of HIF-1 structure

Development perspectives of promising lignocellulose feedstocks for production of advanced generation biofuels: A review

Dunn did not specify how many customers were affected or when they can expect the problem to be resolved.