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Iron overload is a defining feature of ferroptosis, which promotes lipid ROS accumulation by producing hydroxyl and alkoxyl radicals through the Fenton reaction 13
doi: 10.1016/0168-1176(94)04108-J
k cat and K m values could not be obtained due to the low activity of the mutant enzymes
In summary, it can be postulated that during Fe deficiency the accumulation of GSH in cells can activate the vacuolar Fe exporters like AtNRAMP3 and AtNRAMP4 to facilitate Fe export from the vacuolar reserve
Kapahi, P
