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The mechanisms by which PPAR loss leads to aberrant apoptosis and reduced cell survival have been associated to altered lipid metabolism and accumulation of stress and pro-inflammatory molecules such as reactive lipids and ROS deriving from the 5-LO and COX2 pathways, that specifically activate a lipid-mediated programmed cell death [33]

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In female patients with SLE, the increase of 168 mg choline per day was associated with a 10% higher methylation of CD40L promoter (198), Besides these findings, it has not been evaluated whether different forms of dietary choline can modify disease progression or the frequency of flares in SLE patients, neither if the selective inhibition of ACh signaling in B cells can prevent autoreactivity and the severity of organ-specific manifestations

[5] [6] Il metabolismo del glucosio nei soggetti diabetici migliora con la somministrazione sia di ALCAR [7] sia di L-carnitina

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