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Twenty-five of the 137 patients were adolescents (12 to less than 18 years of age)

Conditions including acute hepatitis, cirrhosis, non-alcoholic fatty liver disease (NAFLD), and liver cancer have all been associated with elevated serum B12

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Despite this, ongoing research continues to explore its therapeutic potential, including its effects on knee pain, liver tissue, and alternative therapies for various wounds and tissue injuries

Additionally, the same researchers later treated 4-month-old AD model mice by gavage daily for 5 months, with 25 mg/kg SF, which significantly reduced A plaque levels in the hippocampus and cerebral cortex, improved cognition, and was shown to reduce HDAC 1 and 3 levels, suggesting its potential to counteract A-induced cytotoxicity in AD models [232]

Toll-like receptor (TLR4) pathways mediate proinflammatory cytokine and interferon responses [207]