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doi: 10.1371/journal.pone.0137680

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Headache: The most commonly reported adverse event was headache, characterized as mild to moderate in severity

Our GR activity-related findings may provide a first clue for the mechanism that underlies the heretofore unresolved nature of the intrinsic, pro-mitochondrial effect conferred by parkin [4], namely in the thiol network-related regulation of the cells redox state, which include important redox-sensitive co-factors, such as the ratio of NADP + /NADPH + (Fig