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Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis
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139 Another randomized, double-blind, placebo-controlled pilot trial tested a standardized saffron extract called SafrInside at 30 mg once nightly for four weeks in 52 adults aged 5585 years with sleep complaints

Further studies will focus on identifying specific patient populations that might benefit the most from tesofensine treatment, exploring potential biomarkers for predicting individual responses to the medication

However, CDK4/6 inhibitors were not widely used when the study was initiated
