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In the lungs, O 2 binds to the heme group in Hb

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Also, treatment of rat aortic vascular smooth muscle cells with NO at physiological concentrations resulted in increased cell GSH level and expression of both GCL subunits (Moellering et al., 1998)

10.1196/annals.1297.059 [DOI] [PubMed] [Google Scholar] 46.Estrela JM, Ortega A, Obrador E

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Nrf2 Induces Interleukin-6 (IL-6) Expression via an Antioxidant Response Element within the IL-6 Promoter
