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It also occurs in milder forms with symptoms such as tiredness, weakness, insomnia, depression, or loss of mental sharpness

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This finding holds significant importance, noting that phase 3 studies have typically excluded patients with a history of psychiatric disorders, resulting in a lack of reference data for understanding the long-term consequences of GLP-1 RAs use in patients with obesity

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Across the major clinical programs, most gastrointestinal events were described as mild to moderate in severity, and discontinuation rates were still an important part of how Tirzepatides overall profile was evaluated