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Extreme values of pH may also disrupt the tertiary structure of the enzyme, and so distort the active site, or even denature the enzyme protein

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However, these effects were not observed with oral administration of NMN [124]

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Notably, NS workers demonstrated stronger SARS-CoV-2-specific T-cell responses, and sleep metrics were not significantly associated with vaccine immunogenicity, suggesting that primary immune responses may be resilient to short-term sleep loss in healthy individuals 121

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