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In this pathway, the glutathione peroxidase and glutathione transferase act by removing hydrogen peroxide, while the glutathione reductase reduces the glutathione disulphide to glutathione 9,43

Although several drugs are prescribed for these disorders, some are not able to cross the bloodbrain barrier (BBB), and their efficacy in treated ND is limited

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This introduces additional variability that can obscure the therapeutic signal of a novel compound

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Cohen P.A., Avula B., Katragunta K., Khan I

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