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Decreased availability of DA triggers the symptomatic triad of bradykinesia, tremors-at-rest, and rigidity

Furthermore, ROS may induce oxidative damage to DNA, resulting in strand breakage, nucleotide changes, mutations and, if the DNA damage is severe enough, it can cause cell death [17]

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Catalpol promotes osseointegration of titanium implants under conditions of type 2 diabetes via AKT/GSK3/FYN Pathway-Mediated NRF2 activation

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Lower panels provide a stepbystep use guide (device preparation, injection into lateral thigh or buttock with a 10second hold, and postinjection monitoring) and a triage/dosing algorithm, recommending one injection for mild symptoms and rapid administration of three injections for severe poisoning, with ongoing reassessment