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41(3):576-583, Sept

In particular, clinical heterogeneity complicates the development of robust clinical endpoints, as small and fragmented patient populations often lack sufficient data to establish reliable outcome measures

D., Alimi, M., Grunert, P., Hartl, R
Diabetes (2010) 59(10):255868

Mol Gen Genet 226: 4958, 1991

What else can be missing from the plan
