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I think I will call them, or write them, and simply ask

Moreover, gastrointestinal symptoms often reported by individuals with ME/CFS underscore the potential gut-brain axis involvement in disease manifestation [8, 13]

FEBS Lett 581(2):320324

doi:10.3349/ymj.2021.62.5.446

How the amino acid leucine activates the key cell-growth regulator mTOR

McHugh P