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Statements Author contributions HU: Writingoriginal draft

Tsang T, Posimo JM, Gudiel AA, Cicchini M, Feldser DM, Brady DC

1 Introduction Sepsis-associated encephalopathy (SAE) represents a severe complication of sepsis, defined by diffuse brain dysfunction without direct central nervous system (CNS) infection (Young et al., 1990) and the overall mortality rate remains high at 25%50%, despite advances in critical care

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DE MAMIEL Brightening Cleanse & Exfoliate Ingredients: MOROCCAN LAVA (RHASSOUL) CLAY, KAOLINITE (ROSE CLAY), SODIUM BICARBONATE, MONTMORILLONITE (WHITE CLAY), AVENA SATIVA (COLLODIAL OAT) KERNEL FLOUR*, ASCORBIC ACID (VITAMIN C) POWDER, THEOBROMA CACAO (COCOA) SEED POWDER, BUTYRIS LAC/BUTTERMILK/BABEURRE EN POUDRE POWDER*, ROSA DAMASCENA (ROSE) FLOWER POWDER, CEDRUS DEODARA (HIMALAYAN CEDARWOOD) POWDER, SANTALUM ALBUM (SANDALWOOD) POWDER, BOSWELLIA SERRATA (FRANKINCENSE) RESIN POWDER, VANILLA PLANIFOLIA (VANILLA) BEAN POWDER*, SILICA (ROSE QUARTZ AND RED JASPER) POWDER, SAMBUCUS NIGRA (ELDERFLOWER) FLOWER POWDER, ALTHAEA OFFICINALIS (MARSHMALLOW) ROOT POWDER*, VITIS VINIFERA (GRAPE) SKIN POWDER, SODIUM CHLORIDE (HAWAIIAN ALAEA SEA SALT/MARIS SAL/SEL MARIN), CUCUMIS SATIVUS (CUCUMBER) FRUIT EXTRACT POWDER*, CALENDULA OFFICINALIS (CALENDULA) FLOWER POWDER*, MATRICARIA RECUTITA (GERMAN CHAMOMILE) FLOWER POWDER*, CENTELLA ASIATICA (GOTU KOLA) EXTRACT POWDER*, PANAX GINSENG (GINSENG) ROOT POWDER*, FEVERFEW (CHRYSANTHEMUM) FLOWER POWDER*, EQUISETUM ARVENSE (HORSETAIL) STEM POWDER BESPOKELY BOTANIQUES, CREATED FROM FLOWER AND ENVIRONMENTAL ESSENCES