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Curr Opin Genet Dev

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In contrast, oridonin alone did not demonstrate sufficient efficacy at the same dosage

DNA methylation is a universal epigenetic mechanism characterized by the covalent addition of a methyl group to cytosine in CpG dinucleotides

However, this work once again highlights the remarkable metabolic plasticity of tumour cellsa key aspect of cancer biologywhich allows them to adapt to adverse nutritional conditions and, in many cases, to develop therapy resistance

Advances in technologies and research approaches, such as high-throughput sequencing, single-cell analysis, and genome editing, are providing new opportunities to study DNA methylation and its role in HD more comprehensively